Nonpolarized memory T cells

被引：24

作者：

Kim, CH ^{[1
]}

Campbell, DJ

Butcher, EC

机构：

[1] Stanford Univ, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA

[2] Vet Affairs Palo Alto Hlth Care Syst, Ctr Mol Biol & Med, Palo Alto, CA 94304 USA

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1471-4906(01)02029-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonpolarized T cells, defined as memory T cells that are deficient in the production of T helper 1 (Th1) or Th2 cytokines, are now receiving overdue attention. Predominantly of a lymphoid-tissue-homing phenotype, they comprise a memory T-cell pool for efficient secondary immune responses, as well as a CXC-chemokine receptor 5 (CXCR5)(+) T-cell subset specialized to provide help for B cells. Thus, the conventionally overlooked, nonpolarized T-cell population is proving to have diverse activities important to immune function.

引用

页码：527 / 530

页数：4

共 21 条

[11] Dynamics of T lymphocyte responses: Intermediates, effectors, and memory cells
Lanzavecchia, A
Sallusto, F
[J]. SCIENCE, 2000, 290 (5489) : 92 - 97
[12] Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, David
Vezys, Vaiva
Marzo, Amanda L.
Lefrancois, Leo
[J]. JOURNAL OF IMMUNOLOGY, 2014, 192 (03) : 2413 - 2417
[13] T-cell differentiation: Commitment factors for T helper cells
O'Garra, A
[J]. CURRENT BIOLOGY, 2000, 10 (13) : R492 - R494
[14] Flexibility and cooperation among dendritic cells
Patterson, S
[J]. NATURE IMMUNOLOGY, 2000, 1 (04) : 273 - 274
[15] REGULATION OF TISSUE-SELECTIVE T-LYMPHOCYTE HOMING RECEPTORS DURING THE VIRGIN TO MEMORY EFFECTOR CELL TRANSITION IN HUMAN SECONDARY LYMPHOID-TISSUES
PICKER, LJ
[J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 148 (06): : S47 - S54
[16] Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, RL
Khoruts, A
Merica, R
Zell, T
Jenkins, MK
[J]. NATURE, 2001, 410 (6824) : 101 - 105
[17] Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F
Lenig, D
Förster, R
Lipp, M
Lanzavecchia, A
[J]. NATURE, 1999, 401 (6754) : 708 - 712
[18] CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
Schaerli, P
Willimann, K
Lang, AB
Lipp, M
Loetscher, P
Moser, B
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) : 1553 - 1562
[19] ACQUISITION OF LYMPHOKINE-PRODUCING PHENOTYPE BY CD4+ T-CELLS
SEDER, RA
PAUL, WE
[J]. ANNUAL REVIEW OF IMMUNOLOGY, 1994, 12 : 635 - 673
[20] Tseng J, 1989, Reg Immunol, V2, P50

← 1 2 3 →