Palladium-catalyzed reductive coupling of styrenes and organostannanes under aerobic conditions

被引：86

作者：

Gligorich, Keith M. ^{[1
]}

Cummings, Sarah A. ^{[1
]}

Sigman, Matthew S. ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 46期

关键词：

D O I：

10.1021/ja076746f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a highly regioselective Pd-II-catalyzed reductive coupling of an alkene with an organostannane using a tandem alcohol oxidation under aerobic conditions. Both aryl- and vinylstannanes are competent coupling partners with a variety of styrene derivatives. Mechanistic experiments support a tandem alcohol oxidation/alkene functionalization process. The ability to trap a palladium hydride derived from alcohol oxidation with an alkene provides a fundamentally different approach to cross-coupling reactions.

引用

页码：14193 / +

页数：4

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