A facile synthesis of cephem side chains by palladium catalyzed cross-coupling of 3-substituted-Δ3-cephems with dialkylzinc or vinyltributyltin

被引：6

作者：

Contento, M

Da Col, M

Galletti, P

Sandri, S

Umani-Ronchi, A

机构：

[1] Univ Bologna, Dipartimento Chim G Ciamician, I-40126 Bologna, Italy

[2] Biochim OPOS SpA, I-20041 Agrate Brianza, MI, Italy

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(98)01940-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of 3-vinyl- and 3-alkyl-Delta(3)-cephems was performed in a regioselective manner by palladium acetate catalyzed reaction of 3-sulfonato- or 3-bromo-Delta(3)-cephems with dialkylzinc or vinyltributyltin. A new access to 3-alkyl-Delta(3)-cephems is opened, starting from the allenyl compound 10. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：8743 / 8746

页数：4

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