NUCLEOPHILIC-SUBSTITUTION OF 3-FLUOROSULFONYLOXY CEPHALOSPORINS WITH ORGANOCUPRATES

被引：4

作者：

ROTH, GP

PETERSON, SA

KANT, J

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 45期

关键词：

D O I：

10.1016/S0040-4039(00)79294-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Fluorosulfonyloxy cephems readily undergo addition-elimination reactions with organocuprates derived from the corresponding Grignard reagents. This chemistry presents an efficient, cost effective process for the preparation of 3-substituted cephems.

引用

页码：7229 / 7230

页数：2

共 5 条

[1] REACTIONS OF ORGANOCUPRATES WITH VINYL-TRIFLATES AND RELATED CEPHEMS - A NOVEL-APPROACH TO 3-SUBSTITUTED CEPHALOSPORINS [J].