Therapeutic angiogenesis in cardiovascular disease

被引：246

作者：

Simons, M

Ware, JA ^{[1
]}

机构：

[1] Dartmouth Coll Sch Med, Angiogenesis Res Ctr, Lebanon, NH 03756 USA

[2] Dartmouth Coll Sch Med, Cardiol Sect, Dept Med, Lebanon, NH 03756 USA

[3] Dartmouth Coll Sch Med, Dept Pharmacol & Toxicol, Lebanon, NH 03756 USA

[4] Eli Lilly & Co, Indianapolis, IN 46285 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 11期

关键词：

D O I：

10.1038/nrd1226

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Despite considerable progress in the management of ischaemic cardiovascular disease during the past three decades, there remains a significant population of patients who are not served well by current treatment approaches. Stimulating revascularization in ischaemic regions is an attractive novel therapeutic strategy, and several angiogenic agents anticipated to have the potential to achieve this goal have been clinically evaluated in recent years. However, as yet none have shown sufficient efficacy to be approved. Here, we consider the key findings from the completed clinical trials of therapeutic angiogenesis in cardiovascular disease, and discuss possible changes to the way in which such agents are developed that could improve the chances of success.

引用

页码：863 / 871

页数：9

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