Changing directions in the study of chemotaxis

被引：154

作者：

Kay, Robert R. ^{[1
]}

Langridge, Paul ^{[1
,2
]}

Traynor, David ^{[1
]}

Hoeller, Oliver ^{[1
]}

机构：

[1] MRC Lab Mol Biol, Cambridge CB2 0QH, England

[2] Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 06期

关键词：

D O I：

10.1038/nrm2419

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chemotaxis-the guided movement of cells in chemical gradients-probably first emerged in our single-celled ancestors and even today is recognizably similar in neutrophils and amoebae. Chemotaxis enables immune cells to reach sites of infection, allows wounds to heal and is crucial for forming embryonic patterns. Furthermore, the manipulation of chemotaxis may help to alleviate disease states, including the metastasis of cancer cells. This review discusses recent results concerning how cells orientate in chemotactic gradients and the role of phosphatidylinositol-3,4,5-trisphosphate, what produces the force for projecting pseudopodia and a new role for the endocytic cycle in movement.

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页码：455 / 463

页数：9

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