Changing directions in the study of chemotaxis

被引：154

作者：

Kay, Robert R. ^{[1
]}

Langridge, Paul ^{[1
,2
]}

Traynor, David ^{[1
]}

Hoeller, Oliver ^{[1
]}

机构：

[1] MRC Lab Mol Biol, Cambridge CB2 0QH, England

[2] Columbia Univ Coll Phys & Surg, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 06期

关键词：

D O I：

10.1038/nrm2419

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Chemotaxis-the guided movement of cells in chemical gradients-probably first emerged in our single-celled ancestors and even today is recognizably similar in neutrophils and amoebae. Chemotaxis enables immune cells to reach sites of infection, allows wounds to heal and is crucial for forming embryonic patterns. Furthermore, the manipulation of chemotaxis may help to alleviate disease states, including the metastasis of cancer cells. This review discusses recent results concerning how cells orientate in chemotactic gradients and the role of phosphatidylinositol-3,4,5-trisphosphate, what produces the force for projecting pseudopodia and a new role for the endocytic cycle in movement.

引用

收藏

页码：455 / 463

页数：9

相关论文

共 112 条

[11] Reassembly of contractile actin cortex in cell blebs [J].

Charras, Guillaume T. ;

Hu, Chi-Kuo ;

Coughlin, Margaret ;

Mitchison, Timothy J. .

JOURNAL OF CELL BIOLOGY, 2006, 175 (03) :477-490

[12] Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis [J].

Chen, LF ;

Janetopoulos, C ;

Huang, YE ;

Iijima, M ;

Borleis, J ;

Devreotes, PN .

MOLECULAR BIOLOGY OF THE CELL, 2003, 14 (12) :5028-5037

[13] PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis [J].

Chen, Lingfeng ;

Iijima, Milho ;

Tang, Ming ;

Landree, Mark A. ;

Huang, Yi Elaine ;

Xiong, Yuan ;

Iglesias, Pablo A. ;

Devreotes, Peter N. .

DEVELOPMENTAL CELL, 2007, 12 (04) :603-614

[14] A novel cytosolic regulator, pianissimo, is required for chemoattractant receptor and G protein-mediated activation of the 12 transmembrane domain adenylyl cyclase in Dictyostelium [J].

Chen, MY ;

Long, Y ;

Devreotes, PN .

GENES & DEVELOPMENT, 1997, 11 (23) :3218-3231

[15] The great escape: When cancer cells hijack the genes for chemotaxis and motility [J].

Condeelis, J ;

Singer, RH ;

Segall, JE .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2005, 21 :695-718

[16] ACTIN POLYMERIZATION AND INTRACELLULAR SOLVENT FLOW IN CELL-SURFACE BLEBBING [J].

CUNNINGHAM, CC .

JOURNAL OF CELL BIOLOGY, 1995, 129 (06) :1589-1599

[17] Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks [J].

Delorme, Violaine ;

Machacek, Matthias ;

DerMardirossian, Celine ;

Anderson, Karen L. ;

Wittmann, Torsten ;

Hanein, Dorit ;

Waterman-Storer, Clare ;

Danuser, Gaudenz ;

Bokoch, Gary M. .

DEVELOPMENTAL CELL, 2007, 13 (05) :646-662

[18] Synergistic interaction between the Arp2/3 complex and cofilin drives stimulated lamellipod extension [J].

DesMarais, V ;

Macaluso, F ;

Condeelis, J ;

Bailly, M .

JOURNAL OF CELL SCIENCE, 2004, 117 (16) :3499-3510

[19] Eukaryotic chemotaxis: Distinctions between directional sensing and polarization [J].

Devreotes, P ;

Janetopoulos, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) :20445-20448

[20] Subsecond reorganization of the actin network in cell motility and chemotaxis [J].

Diez, S ;

Gerisch, G ;

Anderson, K ;

Müller-Taubenberger, A ;

Bretschneider, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (21) :7601-7606

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