Immunodeficiencies caused by genetic defects in protein kinases

被引：15

作者：

Notarangelo, LD

机构：

[1] Department of Pediatrics, University of Brescia, Brescia

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0952-7915(96)80028-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The recognition that defects of ZAP-70 and, more recently, of JAK3 kinase in humans result in severe combined immunodeficiency, and the demonstration that targeting of these and other protein-kinase genes in mice also leads to immunodeficiency, have highlighted the crucial role that these proteins play in T-cell differentiation and activation.

引用

收藏

页码：448 / 453

页数：6

相关论文

共 56 条

[51] PP59(FYN) MUTANT MICE DISPLAY DIFFERENTIAL SIGNALING IN THYMOCYTES AND PERIPHERAL T-CELLS [J].

STEIN, PL ;

LEE, HM ;

RICH, S ;

SORIANO, P .

CELL, 1992, 70 (05) :741-750

[52] CYTOKINE SIGNALING THROUGH NONRECEPTOR PROTEIN-TYROSINE KINASES [J].

TANIGUCHI, T .

SCIENCE, 1995, 268 (5208) :251-255

[53] DEFECTS IN B-LYMPHOCYTE MATURATION AND T-LYMPHOCYTE ACTIVATION IN MICE LACKING JAK3 [J].

THOMIS, DC ;

GURNIAK, CB ;

TIVOL, E ;

SHARPE, AH ;

BERG, LJ .

SCIENCE, 1995, 270 (5237) :794-797

[54] PERINATAL LETHALITY AND BLOCKED B-CELL DEVELOPMENT IN MICE LACKING THE TYROSINE KINASE SYK [J].

TURNER, M ;

MEE, PJ ;

COSTELLO, PS ;

WILLIAMS, O ;

PRICE, AA ;

DUDDY, LP ;

FURLONG, MT ;

GEAHLEN, RL ;

TYBULEWICZ, VLJ .

NATURE, 1995, 378 (6554) :298-302

[55] WHAT TO DO AT AN END - DNA DOUBLE-STRAND-BREAK REPAIR [J].

WEAVER, DT .

TRENDS IN GENETICS, 1995, 11 (10) :388-392

[56] T-CELL AND B-CELL TOLERANCE AND RESPONSES TO VIRAL-ANTIGENS IN TRANSGENIC MICE - IMPLICATIONS FOR THE PATHOGENESIS OF AUTOIMMUNE VERSUS IMMUNOPATHOLOGICAL DISEASE [J].

ZINKERNAGEL, RM ;

PIRCHER, HP ;

OHASHI, P ;

OEHEN, S ;

ODERMATT, B ;

MAK, T ;

ARNHEITER, H ;

BURKI, K ;

HENGARTNER, H .

IMMUNOLOGICAL REVIEWS, 1991, 122 :133-171

← 1 2 3 4 5 6 →