A catalytic asymmetric method for the synthesis of γ-unsaturated β-amino acid derivatives

被引:87
作者
Lurain, AE [1 ]
Walsh, PJ [1 ]
机构
[1] Univ Penn, Dept Chem, P Roy & Diana T Vagelos Labs, Philadelphia, PA 19104 USA
关键词
D O I
10.1021/ja035213d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Catalytic enantioselective synthesis of beta-amino acid derivatives is an area of intense interest, due to the importance of these compounds as components in pharmaceutical agents and peptidomimetics. In this report, we present the first catalytic enantioselective method for the synthesis of gamma-unsaturated beta-amino acids and their corresponding 1,3-amino alcohol derivatives. This methodology takes advantage of a highly enantioselective vinylzinc addition to an aldehyde to set chirality. The resulting allylic alcohols are then transformed into the corresponding allylic amines via Overman's [3,3]-sigmatropic imidate rearrangement, and subsequent one-pot deprotection-oxidation of a pendant oxygen leads to the gamma-unsaturated beta-amino acid derivatives of high enantiopurity.
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页码:10677 / 10683
页数:7
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