Urate: a novel biomarker of Parkinson's disease risk, diagnosis and prognosis

被引：92

作者：

Cipriani, S. ^{[1
]}

Chen, Xiqun ^{[1
]}

Schwarzschild, Michael A. ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Boston, MA 02129 USA

来源：

BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 05期

关键词：

blood; cerebrospinal fluid; oxidative stress; Parkinson's disease; prognosis; substantia nigra; urate; SERUM URIC-ACID; BLOOD-BRAIN-BARRIER; PLASMA URATE; OXIDANT STRESS; PEROXYNITRITE; CONSUMPTION; PROGRESSION; METABOLISM; RADICALS; ALCOHOL;

D O I：

10.2217/BMM.10.94

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A growing number of studies have correlated higher urate levels with a lower risk of developing Parkinson's disease (PD) and with a favorable rate of disease progression, indicating that urate could be an important biomarker of the pathophysiology underlying PD. Dietary and genetic determinants of urate have also been linked to a reduced risk or delayed onset of PD. Based on the known antioxidant and metal complexing properties of urate, together with evidence for oxidative stress as a contributor to neurodegeneration in PD, urate may serve as an endogenous neuroprotectant that helps reduce the risk and rate of the disease. In this article we review the convergent biological, epidemiological and clinical data that identify urate as a promising biomarker of the risk, diagnosis and prognosis of PD.

引用

收藏

页码：701 / 712

页数：12

相关论文

共 82 条

[61]

Palacios N, 2010, AM J EPIDEMIOL, V171, pS149

[62] Consumption of milk and calcium in midlife and the future risk of Parkinson disease [J].

Park, M ;

Ross, GW ;

Petrovitch, H ;

White, LR ;

Masaki, KH ;

Nelson, JS ;

Tanner, CM ;

Curb, JD ;

Blanchette, PL ;

Abbott, RD .

NEUROLOGY, 2005, 64 (06) :1047-1051

[63] Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals [J].

Regoli, F ;

Winston, GW .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1999, 156 (02) :96-105

[64] Serum urate as a predictor of clinical and radiographic progression in Parkinson disease [J].

Schwarzschild, Michael A. ;

Schwid, Steven R. ;

Marek, Kenneth ;

Watts, Arthur ;

Lang, Anthony E. ;

Oakes, David ;

Shoulson, Ira ;

Ascherio, Alberto .

ARCHIVES OF NEUROLOGY, 2008, 65 (06) :716-723

[65] DATATOP - A MULTICENTER CONTROLLED CLINICAL-TRIAL IN EARLY PARKINSONS-DISEASE [J].

SHOULSON, I .

ARCHIVES OF NEUROLOGY, 1989, 46 (10) :1052-1060

[66] Development and validation of biomarker classifiers for treatment selection [J].

Simon, Richard .

JOURNAL OF STATISTICAL PLANNING AND INFERENCE, 2008, 138 (02) :308-320

[67] Nitrosation of uric acid by peroxynitrite - Formation of a vasoactive nitric oxide donor [J].

Skinner, KA ;

White, CR ;

Patel, R ;

Tan, S ;

Barnes, S ;

Kirk, M ;

Darley-Usmar, V ;

Parks, DA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (38) :24491-24497

[68] Uric acid transport and disease [J].

So, Alexander ;

Thorens, Bernard .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (06) :1791-1799

[69] Association of Common Polymorphisms in GLUT9 Gene with Gout but Not with Coronary Artery Disease in a Large Case-Control Study [J].

Stark, Klaus ;

Reinhard, Wibke ;

Neureuther, Katharina ;

Wiedmann, Silke ;

Sedlacek, Kamil ;

Baessler, Andrea ;

Fischer, Marcus ;

Weber, Stefan ;

Kaess, Bernhard ;

Erdmann, Jeanette ;

Schunkert, Heribert ;

Hengstenberg, Christian .

PLOS ONE, 2008, 3 (04)

[70] Origin and functional consequences of the complex I defect in Parkinson's disease [J].

Swerdlow, RH ;

Parks, JK ;

Miller, SW ;

Tuttle, JB ;

Trimmer, PA ;

Sheehan, JP ;

Bennett, JP ;

Davis, RE ;

Parker, WD .

ANNALS OF NEUROLOGY, 1996, 40 (04) :663-671

← 1 2 3 4 5 6 7 8 9 →