Unraveling the chemistry of chemokine receptor ligands

被引：45

作者：

Gao, ZL ^{[1
]}

Metz, WA ^{[1
]}

机构：

[1] Aventis Pharmaceut, Med Chem, Bridgewater, NJ 08807 USA

来源：

CHEMICAL REVIEWS | 2003年 / 103卷 / 09期

关键词：

D O I：

10.1021/cr020474b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The study of chemokine receptors and their ligands is a rapidly growing and intense area of research in drug discovery. There is now extensive evidence for the involvement of chemokines in many disease pathways, and thus continued research to discover small-molecule chemokine receptor antagonists for these targets is warranted. To date, there has been significant progress in the identification of small-molecule nanomolar chemokine antagonists that are bioavailable. It is extremely encouraging that this class of GPCRs can be antagonized with low-molecular-weight small organic compounds.

引用

页码：3733 / 3752

页数：20

共 147 条

[11]

Berger EA, 1997, AIDS, V11, pS3

[12]

BONNERT R, 2001, Patent No. 162758

[13]

BRATTON LD, 2001, Patent No. 0179209

[14]

BRIDGER G, 2000, Patent No. 0056729

[15] Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV-8 replication by antagonism of the chemokine receptor CXCR4 [J].

Bridger, GJ ;

Skerlj, RT ;

Padmanabhan, S ;

Martellucci, SA ;

Henson, GW ;

Struyf, S ;

Witvrouw, M ;

Schols, D ;

De Clercq, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (19) :3971-3981

[16] INTERLEUKIN-8 IS A MAJOR NEUTROPHIL CHEMOTACTIC FACTOR IN PLEURAL LIQUID OF PATIENTS WITH EMPYEMA [J].

BROADDUS, VC ;

HEBERT, CA ;

VITANGCOL, RV ;

HOEFFEL, JM ;

BERNSTEIN, MS ;

BOYLAN, AM .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 146 (04) :825-830

[17]

BROWN MF, 2001, Patent No. [0157023, 00157023]

[18] Regulation of hematopoiesis by chemokine family members [J].

Broxmeyer, HE .

INTERNATIONAL JOURNAL OF HEMATOLOGY, 2001, 74 (01) :9-17

[19]

BRYAN DL, 1999, Patent No. 9936069

[20]

BRYAN DL, 2001, Patent No. 034141

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