Modified guanidines as potential chiral superbases. 1. Preparation of 1,3-disubstituted 2-iminoimidazolidines and the related guanidines through chloroamidine derivatives

被引：97

作者：

Isobe, T

Fukuda, K

Ishikawa, T

机构：

[1] Chiba Univ, Fac Pharmaceut Sci, Chiba 2638522, Japan

[2] Shiratori Pharmaceut Co Ltd, Cent Res Lab, Narashino, Chiba 2750016, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 23期

关键词：

D O I：

10.1021/jo000744v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Modified guanidines were explored as potential chiral superbases. Thus, chiral 1,3-dimethyl-2-iminoimidazolidines with or without 4,5-diphenyl groups, their guanidinium salts, and the 2-iminoimidazolidines with (S)-1-phenylethyl groups on the ring nitrogens were prepared by treatment of 2-chloroimidazolinium chlorides with appropriate amines. Bicyclic guanidines were also prepared from a prolinamide using a similar procedure.

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页码：7770 / 7773

页数：4

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