(R)-3,5-diCF3-SYNPHOS and (R)-p-CF3-SYNPHOS, Electron-Poor Diphosphines for Efficient Room Temperature Rh-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids

被引：52

作者：

Berhal, Farouk ^{[1
]}

Esseiva, Olivier ^{[1
]}

Martin, Charles-Henri ^{[1
]}

Tone, Hitoshi ^{[1
]}

Genet, Jean-Pierre ^{[1
]}

Ayad, Tahar ^{[1
]}

Ratovelomanana-Vidal, Virginie ^{[1
]}

机构：

[1] Chim ParisTech, CNRS, Lab Charles Friedel, UMR 7223, F-75231 Paris 05, France

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 11期

关键词：

LIGANDS; RHODIUM; HYDROGENATION; 1,4-ADDITION; DIFLUORPHOS; COMPLEXES; PALLADIUM; ESTERS; RESOLUTION; KETONES;

D O I：

10.1021/ol200495a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new atropisomeric electron-poor chiral diphosphine ligand analogues of SYNPHOS were prepared, and their electronic properties are described. These two ligands afforded high performance for the Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to alpha,beta-unsaturated carbonyl compounds at room temperature.

引用

页码：2806 / 2809

页数：4

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