New enantioselective synthesis of monofluorinated pyridines designed for the preparation of chemical libraries

被引：27

作者：

Blayo, Anne-Laure ^{[1
]}

Le Meur, Stephanie ^{[2
]}

Gree, Danielle ^{[1
]}

Gree, Rene ^{[1
]}

机构：

[1] Univ Rennes 1, Lab Synth & Electrosynth Organ, CNRS, UMR 6510, F-35042 Rennes, France

[2] Bioprojet Biotech, F-35762 St Gregoire, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 03期

关键词：

chemical libraries; fluorides; fluorination; pyridines;

D O I：

10.1002/adsc.200700488

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Chiral pyridines with a fluorine atom in the benzylic position are easily accessible from optically active propargylic fluorides by using the Bohlmann-Rahtz reaction. Such pyridines, possessing four points of molecular diversity, are useful scaffolds for the preparation of chemical libraries.

引用

页码：471 / 476

页数：6

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