The bohimann-rahtz pyridine synthesis: From discovery to applications

被引：206

作者：

Bagley, Mark C. ^{[1
]}

Glover, Christian ^{[1
]}

Merritt, Eleanor A. ^{[1
]}

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, Wales

来源：

SYNLETT | 2007年 / 16期

关键词：

pyridines; heterocycles; enamines; multicomponent; reactions; microwave synthesis; natural products;

D O I：

10.1055/s-2007-986674

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The results of our research into the Bohlmann-Rahtz pyridine synthesis are summarized. The historic discovery of this reaction and its mechanism are discussed; followed by recent improvements in methodology, such as Bronsted and Lewis acid catalysis, microwave assistance, process in a continuous flow reactor, and incorporation into multicomponent and tandem reactions. Applications of these methods in the synthesis of pyrido[2,3-d]pyrimidines, combinatorial pyridine libraries, heterocyclic a- and gamma-amino acids, a-helix mimetics, and complex natural products are discussed, along with a consideration of future perspectives.

引用

收藏

页码：2459 / 2482

页数：24

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