MMPs in the central nervous system: Where the good guys go bad

被引：171

作者：

Agrawal, Smriti M.

Lau, Lorraine

Yong, V. Wee ^{[1
]}

机构：

[1] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB T2N 4N1, Canada

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2008年 / 19卷 / 01期

关键词：

proteases; neural development; neuroinflammation; multiple sclerosis;

D O I：

10.1016/j.semcdb.2007.06.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Matrix metalloproteinases ( MMPs) are expressed in the developing, healthy adult and diseased CNS. We emphasize the regulation of neurogenesis and oligodendrogenesis by MMPs during CNS development, and highlight physiological roles of MMPs in the healthy adult CNS, such as in synaptic plasticity, learning and memory. Nonetheless, MMPs as "the good guys" go bad in neurological conditions, likely aided by the sudden and massive upregulation of several MMP members. We stress the necessity of drawing a fine balance in the treatment of neurological diseases, and we suggest that MMP inhibitors do have therapeutic potential early after CNS injury. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：42 / 51

页数：10

共 117 条

[111] Metalloproteinases: Mediators of pathology and regeneration in the CNS [J].