Stereoselective Grignard-type reactions of chiral N,N-dibenzylamino ketones

被引：11

作者：

Reetz, MT

Schmitz, A

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

[2] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期

关键词：

amino acids and derivatives; amino alcohols; Grignard reactions/reagents; asymmetric induction;

D O I：

10.1016/S0040-4039(99)00359-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-N-Dibenzylamino ketones of the type Bn2N(R-1)CHC(O)R-2, prepared in enantiomerically pure form from alpha-amino acids, undergo non-chelation controlled Grignard-type reactions with RLi, RMgX or RCeCl2 without any undesired racemization. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2737 / 2740

页数：4

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