Stereoselective Grignard-type reactions of chiral N,N-dibenzylamino ketones

被引:11
作者
Reetz, MT
Schmitz, A
机构
[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany
[2] Univ Marburg, Fachbereich Chem, D-35043 Marburg, Germany
关键词
amino acids and derivatives; amino alcohols; Grignard reactions/reagents; asymmetric induction;
D O I
10.1016/S0040-4039(99)00359-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
N-N-Dibenzylamino ketones of the type Bn2N(R-1)CHC(O)R-2, prepared in enantiomerically pure form from alpha-amino acids, undergo non-chelation controlled Grignard-type reactions with RLi, RMgX or RCeCl2 without any undesired racemization. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2737 / 2740
页数:4
相关论文
共 30 条