Lead compounds discovered from libraries

被引：95

作者：

Golebiowski, A ^{[1
]}

Klopfenstein, SR ^{[1
]}

Portlock, DE ^{[1
]}

机构：

[1] Procter & Gamble Pharmaceut, Hlth Care Res Ctr, Mason, OH 45040 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(00)00203-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.

引用

页码：273 / 284

页数：12

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