Transmission blocking malaria vaccines

被引：162

作者：

Carter, R ^{[1
]}

机构：

[1] Univ Edinburgh, Div Biol Sci, Edinburgh EH9 3JT, Midlothian, Scotland

来源：

VACCINE | 2001年 / 19卷 / 17-19期

关键词：

malaria; transmission; vaccine;

D O I：

10.1016/S0264-410X(00)00521-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transmission blocking vaccines (TBVs) against malaria are intended to induce immunity against the stages of the parasites which infect mosquitoes so that TBV-immunised individuals cannot transmit malaria. As malarial infections are transmitted mainly within a few hundreds of meters from an infectious human source, TBVs used within in a community would protect the immediate neighbourhood of the vaccinated individuals. TBVs against the two major species of human malaria, Plasmodium falciparum and P. vivax. are under development. Candidate TBV constructs for both Plasmodium species have been successfully tested in animal systems and testing is in progress with clinical grade material in humans. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：2309 / 2314

页数：6

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