A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines

被引：147

作者：

Duffy, PE

Kaslow, DC

机构：

[1] NIAID,PARASIT DIS LAB,MALARIA VACCINES SECT,NIH,BETHESDA,MD 20892

[2] WALTER REED ARMY INST RES,DEPT IMMUNOL,WASHINGTON,DC 20307

来源：

INFECTION AND IMMUNITY | 1997年 / 65卷 / 03期

关键词：

D O I：

10.1128/IAI.65.3.1109-1113.1997

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antibodies to Pfs28 block Plasmodium falciparum transmission and when combined with antibodies to Pfs25 provide synergy in blocking transmission. Pfs28 and Pfs25 are immunogenic, have limited antigenic diversity, and are structurally similar and genetically linked on chromosome 10. Pfs28 may prove a useful addition to Pfs25 in an effective transmission-blocking vaccine.

引用

收藏

页码：1109 / 1113

页数：5

相关论文

共 14 条

[1] RECOMBINANT PFS25 PROTEIN OF PLASMODIUM-FALCIPARUM ELICITS MALARIA TRANSMISSION-BLOCKING IMMUNITY IN EXPERIMENTAL-ANIMALS [J].

BARR, PJ ;

GREEN, KM ;

GIBSON, HL ;

BATHURST, IC ;

QUAKYI, IA ;

KASLOW, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (05) :1203-1208

[2] PGS28 BELONGS TO A FAMILY OF EPIDERMAL GROWTH-FACTOR LIKE ANTIGENS THAT ARE TARGETS OF MALARIA TRANSMISSION-BLOCKING ANTIBODIES [J].

DUFFY, PE ;

PIMENTA, P ;

KASLOW, DC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :505-510

[3] ANTIGENIC DIVERSITY AND THE TRANSMISSION DYNAMICS OF PLASMODIUM-FALCIPARUM [J].

GUPTA, S ;

TRENHOLME, K ;

ANDERSON, RM ;

DAY, KP .

SCIENCE, 1994, 263 (5149) :961-963

[4] SACCHAROMYCES-CEREVISIAE RECOMBINANT PFS25 ADSORBED TO ALUM ELICITS ANTIBODIES THAT BLOCK TRANSMISSION OF PLASMODIUM-FALCIPARUM [J].

KASLOW, DC ;

BATHURST, IC ;

LENSEN, T ;

PONNUDURAI, T ;

BARR, PJ ;

KEISTER, DB .

INFECTION AND IMMUNITY, 1994, 62 (12) :5576-5580

[5] COMPARISON OF THE PRIMARY STRUCTURE OF THE 25 KDA OOKINETE SURFACE-ANTIGENS OF PLASMODIUM-FALCIPARUM AND PLASMODIUM-GALLINACEUM REVEAL 6 CONSERVED REGIONS [J].

KASLOW, DC ;

SYIN, C ;

MCCUTCHAN, TF ;

MILLER, LH .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 33 (03) :283-287

[6] TRANSMISSION-BLOCKING IMMUNITY AGAINST MALARIA AND OTHER VECTOR-BORNE DISEASES [J].

KASLOW, DC .

CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (04) :557-565

[7] A VACCINE CANDIDATE FROM THE SEXUAL STAGE OF HUMAN MALARIA THAT CONTAINS EGF-LIKE DOMAINS [J].

KASLOW, DC ;

QUAKYI, IA ;

SYIN, C ;

RAUM, MG ;

KEISTER, DB ;

COLIGAN, JE ;

MCCUTCHAN, TF ;

MILLER, LH .

NATURE, 1988, 333 (6168) :74-76

[8]

KASLOW DC, 1994, BIO-TECHNOL, V12, P494, DOI 10.1038/nbt0594-494

[9]

KASLOW DC, 1993, VACCINE RES, V2, P95

[10] STRUCTURE AND EXPRESSION OF A POSTTRANSCRIPTIONALLY REGULATED MALARIA GENE ENCODING A SURFACE PROTEIN FROM THE SEXUAL STAGES OF PLASMODIUM-BERGHEI [J].

PATON, MG ;

BARKER, GC ;

MATSUOKA, H ;

RAMESAR, J ;

JANSE, CJ ;

WATERS, AP ;

SINDEN, RE .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1993, 59 (02) :263-275