Protein folding: Then and now

被引：76

作者：

Chen, Yiwen ^{[1
]}

Ding, Feng ^{[1
]}

Nie, Huifen ^{[1
]}

Serohijos, Adrian W. ^{[1
]}

Sharma, Shantanu ^{[1
]}

Wilcox, Kyle C. ^{[1
]}

Yin, Shuangye ^{[1
]}

Dokholyan, Nikolay V. ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biochem & Biophys, Sch Med, Chapel Hill, NC 27599 USA

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 2008年 / 469卷 / 01期

关键词：

protein folding; misfolding; aggregation; folding kinetics; protein thermodynamics; discrete molecular dynamics (DMD);

D O I：

10.1016/j.abb.2007.05.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past three decades the protein folding field has undergone monumental changes. Originally a purely academic question, how a protein folds has now become vital in understanding diseases and our abilities to rationally manipulate cellular life by engineering protein folding pathways. We review and contrast past and recent developments in the protein folding field. Specifically, we discuss the progress in our understanding of protein folding thermodynamics and kinetics, the properties of evasive intermediates, and unfolded states. We also discuss how some abnormalities in protein folding lead to protein aggregation and human diseases. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：4 / 19

页数：16

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