Genetic polymorphisms of macrophage-mediators in Guillain-Barre syndrome

被引：34

作者：

Geleijns, Karin

Emonts, Marieke

Laman, Jon D.

van Rijs, Wouter

van Doorn, Pieter A.

Hermans, Peter W. M.

Jacobs, Bart C.

机构：

[1] Erasmus MC, Dept Neurol, NL-3015 CE Rotterdam, Netherlands

[2] Erasmus MC, Dept Immunol, NL-3015 CE Rotterdam, Netherlands

[3] Erasmus MC, Dept Paediat, NL-3015 CE Rotterdam, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Paediat, Nijmegen, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 190卷 / 1-2期

关键词：

Autoimmunity; peripheral nerve system; genetic analysis;

D O I：

10.1016/j.jneuroim.2007.07.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Macrophages infiltrate peripheral nerves and may contribute to neural damage in the Guillain-Barre syndrome (GBS). We determined whether single nucleotide polymorphisms (SNP) in genes encoding macrophage-mediators are related to the susceptibility and severity of GBS. The frequencies of SNP in the TNFA, MMP9, IL10, and NOS2a genes did not differ between 263 GBS patients and 2 10 healthy subjects. The MMP9 C(-1562)T and TNFA C(-863)A SNP were associated with severe weakness and poor outcome, indicating that these SNP may be one of the factors predisposing to a severe form of GBS. (C) 2007 Elsevier B.V. All rights reserved.

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收藏

页码：127 / 130

页数：4

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