Interleukin-10 promoter polymorphisms in patients with Guillain-Barre syndrome

被引：33

作者：

Myhr, KM ^{[1
]}

Vågnes, KS ^{[1
]}

Maroy, TH ^{[1
]}

Aarseth, JH ^{[1
]}

Nyland, HI ^{[1
]}

Vedeler, CA ^{[1
]}

机构：

[1] Univ Bergen, Haukeland Hosp, Multiple Sclerosis Natl Competence Ctr, Dept Neurol, N-5021 Bergen, Norway

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2003年 / 139卷 / 1-2期

关键词：

IL-10 promoter polymorphism; Guillain-Barre syndrome; disease susceptibility; clinical course; disability;

D O I：

10.1016/S0165-5728(03)00133-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Interleukin-10 (IL-10) may have both pro- and anti-inflammatory effects in Guillain-Barre syndrome (GBS). The distribution of polymorphisms in the IL-10 gene (-1082 (G/A), -819 (T/C) and -592 (A/C)) was analysed to determine whether they could influence disease susceptibility or clinical course in GBS. The -592 CC and -819 CC genotypes associated with increased IL-10 response were more frequent in the GBS patients than in the controls (P=0.027), but the polymorphisms did not influence the clinical course of the disease. (C) 2003 Elsevier Science B.V. All rights reserved.

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收藏

页码：81 / 83

页数：3

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