IgG Fc-receptor polymorphisms in Guillain-Barre syndrome

被引:33
作者
Vedeler, CA [1 ]
Raknes, G [1 ]
Myhr, KM [1 ]
Nyland, H [1 ]
机构
[1] Univ Bergen, Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway
关键词
D O I
10.1212/WNL.55.5.705
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The authors studied immunoglobulin G (IgG) Fc receptor (Fc gamma R.) IIA, IIIA, and IIIB polymorphisms in 62 patients with Guillain-Barre syndrome (GBS) and in 89 healthy controls. The Fc gamma R genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls. Patients homozygous for the Fc gamma RIIIB neutrophil antigen (NA) 1 allele had a significantly less severe disease than patients heterozygous or homozygous for the NA2 allele. The Fc gamma RIIIB NA1/NA1 genotype has high affinity for IgG1 and IgG3, and clearance of circulating autoantibodies and immune complexes may therefore be of importance in the pathogenesis of GBS.
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页码:705 / 707
页数:3
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