Phosphate based glasses for biomedical applications

被引:366
作者
Knowles, JC [1 ]
机构
[1] UCL, Eastman Dent Inst, Div Biomat & Tissue Engn, London WC1X 8LD, England
关键词
D O I
10.1039/b307119g
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
Biomaterials and tissue engineering are rapidly expanding fields for research and also commercial exploitation. A greater understanding of the interaction of materials with cells has allowed implant materials to be designed with the aim of promoting a specific biological response. Phosphate-based glasses are a unique group of materials that offer great potential for hard and soft tissue engineering. The move from passive inert implant materials to active degradable materials indicates that phosphate glasses may have a role in tissue engineering. Whilst significant work has been carried out to elucidate the structure of these materials, there is a paucity of data to correlate this information with the physical properties such as dissolution rate. This paper details some of the basic properties of these materials and how these may be exploited in the design of a biomaterial. Also a review of some of the current and potential clinical uses for these materials is included.
引用
收藏
页码:2395 / 2401
页数:7
相关论文
共 64 条
[31]   NUCLEAR-MAGNETIC-RESONANCE INVESTIGATION OF THE STRUCTURES OF PHOSPHATE AND PHOSPHATE-CONTAINING GLASSES - A REVIEW [J].
KIRKPATRICK, RJ ;
BROW, RK .
SOLID STATE NUCLEAR MAGNETIC RESONANCE, 1995, 5 (01) :9-21
[32]  
Knowles J. C., 1994, BIOCERAMICS, V7, P85
[33]   DEVELOPMENT OF A DEGRADABLE COMPOSITE FOR ORTHOPEDIC USE - INVIVO BIOMECHANICAL AND HISTOLOGICAL-EVALUATION OF 2 BIOACTIVE DEGRADABLE COMPOSITES BASED ON THE POLYHYDROXYBUTYRATE POLYMER [J].
KNOWLES, JC ;
HASTINGS, GW ;
OHTA, H ;
NIWA, S ;
BOEREE, N .
BIOMATERIALS, 1992, 13 (08) :491-496
[34]   AN INTELLIGENT DEGRADABLE POLYMER COMPOSITE WHICH CLOSELY MATCHES BONE [J].
KNOWLES, JC ;
HASTINGS, GW .
JOURNAL OF INTELLIGENT MATERIAL SYSTEMS AND STRUCTURES, 1994, 5 (01) :122-126
[35]   Investigation of the solubility and ion release in the glass system K2O-Na2O-CaO-P2O5 [J].
Knowles, JC ;
Franks, K ;
Abrahams, I .
BIOMATERIALS, 2001, 22 (23) :3091-3096
[36]   INVITRO AND INVIVO INVESTIGATION OF A RANGE OF PHOSPHATE GLASS-REINFORCED POLYHYDROXYBUTYRATE-BASED DEGRADABLE COMPOSITES [J].
KNOWLES, JC ;
HASTINGS, GW .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 1993, 4 (02) :102-106
[37]  
Latia A, 2003, J OPTOELECTRON ADV M, V5, P185
[38]   Biodegradable controlled release glass in the repair of peripheral nerve injuries [J].
Lenihan, DV ;
Carter, AJ ;
Gilchrist, T ;
Healy, DM ;
Miller, LM ;
Glasby, MA .
JOURNAL OF HAND SURGERY-BRITISH AND EUROPEAN VOLUME, 1998, 23B (05) :588-593
[39]   OXYNITRIDE GLASSES [J].
LOEHMAN, RE .
JOURNAL OF NON-CRYSTALLINE SOLIDS, 1980, 42 (1-3) :433-445
[40]   PROPERTIES OF ER3+-DOPED PHOSPHATE-GLASSES AND GLASS-FIBERS AND EFFICIENT INFRARED TO VISIBLE UP-CONVERSION [J].
LU, YL ;
MING, NB .
JOURNAL OF MATERIALS SCIENCE, 1995, 30 (22) :5705-5710