Unprecedented Negishi coupling at C-Br in the presence of a stannyl group as a convenient approach to pyridinylstannanes and their application in liquid crystal synthesis

被引：38

作者：

Getmanenko, Yulia A. ^{[1
]}

Twieg, Robert J. ^{[1
]}

机构：

[1] Kent State Univ, Dept Chem, Kent, OH 44242 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 03期

关键词：

D O I：

10.1021/jo701812t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The 2-bromo-5(or 6)-tri-n-butylstannylpyridines, prepared from dibromopyridines and i-PrMgCl at room temperature, undergo Negishi coupling with either alkyl or arylzinc chlorides. The new alkyl- and aryl-substituted pyridylstannanes produced are shown to be suitable for further functionalization by Stille coupling. A group of new liquid crystalline materials with aromatic cores comprised of pyridine and thiophene rings were prepared utilizing these new pyridinylstannanes as key intermediates.

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页码：830 / 839

页数：10

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