Occurrence of paralytic shellfish poison in Bangladeshi freshwater puffers

被引：52

作者：

Zaman, L ^{[1
]}

Arakawa, O ^{[1
]}

Shimosu, A ^{[1
]}

Onoue, Y ^{[1
]}

机构：

[1] KAGOSHIMA UNIV, FAC FISHERIES, LAB MARINE BOT & ENVIRONM SCI, KAGOSHIMA 890, JAPAN

来源：

TOXICON | 1997年 / 35卷 / 03期

关键词：

D O I：

10.1016/S0041-0101(96)00167-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two species of freshwater puffer fish, Tetraodon cutcutia and Chelonodon patoca, collected from several locations in Bangladesh, showed lethal potency in mice ranging from 2.0 to 40.0 MU/g tissue as paralytic shellfish poison. In both species, toxicity of the skin was generally higher than the other tissues examined (muscle, liver and ovary). Water-soluble toxins from T. cutcutia were partially purified by activated charcoal treatment followed by column chromatographies using Bio-Gel P-2 and Bio-Rex 70. Analyses by cellulose acetate membrane electrophoresis and high-performance liquid chromatography with fluorometric detection demonstrated that the toxins were composed of saxitoxin, decarbamoylsaxitoxin, gonyautoxins 2 and 3. decarbamoylgonyautoxins 2 and 3, and three unidentified components which are possibly related to paralytic shellfish poison. (C) 1997 Elsevier Science Ltd.

引用

页码：423 / 431

页数：9

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