Plasma levels of interleukin-6 and C-reactive protein are associated with physical inactivity independent of obesity

被引:159
作者
Fischer, C. P.
Berntsen, A.
Perstrup, L. B.
Eskildsen, P.
Pedersen, B. K.
机构
[1] Univ Copenhagen Hosp, Rigshosp, Dept Infect Dis, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Fac Hlth Sci, Rigshosp,Dept Infect Dis, Copenhagen Muscle Res Ctr,Ctr Inflammat & Metab, Copenhagen, Denmark
[3] Roskilde County Hosp, Dept Med, Koge, Denmark
关键词
age; cytokines; exercise; inflammation; obesity; physical activity;
D O I
10.1111/j.1600-0838.2006.00602.x
中图分类号
G8 [体育];
学科分类号
04 ; 0403 ;
摘要
It is recognized that the path from physical inactivity and obesity to lifestyle-related diseases involves low-grade inflammation, indicated by elevated plasma levels of inflammatory markers. Interestingly, contracting skeletal muscle is a major source of circulating interleukin-6 (IL-6) in response to acute exercise, but with a markedly lower response in trained subjects. As C-reactive protein (CRP) is induced by IL-6, we hypothesized that basal levels of IL-6 and CRP reflect the degree of regular physical activity when compared with other markers of inflammation associated with lifestyle-related morbidity. Fasting plasma/serum levels of IL-6, IL-18, CRP, tumur necrosis factor-alpha (TNF-alpha), soluble TNF receptor II (sTNF-RII), and adiponectin were measured in healthy non-diabetic men and women (n=84). The amount of leisure-time physical activity (LTPA) was assessed by interview. Obesity was associated with elevated insulin, C-peptide, triglycerides, low-density lipoprotein, IL-6, CRP, and adiponectin (all P < 0.05). Importantly, physical inactivity was associated with elevated C-peptide (P=0.036), IL-6 (P=0.014), and CRP (P=0.007) independent of obesity, age, gender, and smoking. Furthermore, the LTPA score was inversely associated with IL-6 (P=0.017) and CRP (P=0.005), but with neither of the other markers. The results indicate that low levels of IL-6 and CRP - not IL-18, TNF-alpha, sTNF-RII, or adiponectin - reflect regular physical activity.
引用
收藏
页码:580 / 587
页数:8
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