Photoacoustic imaging of vascular networks in transgenic mice

被引：8

作者：

Laufer, J. G. ^{[1
]}

Cleary, J. O. ^{[1
]}

Zhang, E. Z. ^{[1
]}

Lythgoe, M. F. ^{[2
,3
]}

Beard, P. C. ^{[1
]}

机构：

[1] UCL, Dept Med Phys & Bioengn, London WC1E 6BT, England

[2] UCL, Dept Med, London WC1E 6BT, England

[3] UCL, UCL Inst Child Hlth, London WC1E 6BT, England

来源：

PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2010 | 2010年 / 7564卷

关键词：

D O I：

10.1117/12.842204

中图分类号：

O43 [光学];

学科分类号：

070207 [光学];

摘要：

The preferential absorption of near infrared light by blood makes photoacoustic imaging well suited to visualising vascular structures in soft tissue. In addition, the spectroscopic specificity of tissue chromophores can be exploited by acquiring images at multiple excitation wavelengths. This allows the quantification of endogenous chromophores, such as oxy- and deoxyhaemoglobin, and hence blood oxygenation, and the detection of exogenous chromophores, such as functionalised contrast agents. More importantly, this approach has the potential to visualise the spatial distribution of low concentrations of functionalised contrast agents against the strong background absorption of the endogenous chromophores. This has a large number of applications in the life sciences. One example is the structural and functional phenotyping of transgenic mice for the study of the genetic origins of vascular malformations, such as heart defects. In this study, photoacoustic images of mouse embryos have been acquired to study the development of the vasculature following specific genetic knockouts.

引用

页数：5

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