Effects of bromocriptine and/or L-DOPA on neurons in substantia nigra of MPTP-treated C57BL/6 mice

被引：16

作者：

Fukuda, T

Watabe, K

Tanaka, J

机构：

[1] Division of Neuropathology, Institute of Neuroscience, Jikei Univ. School of Medicine, Tokyo 105, 3-25-8 Nishi-shinbashi, Minato-ku

来源：

BRAIN RESEARCH | 1996年 / 728卷 / 02期

关键词：

Parkinsonism; bromocriptine; L-DOPA; C57BL/6; mouse; MPTP;

D O I：

10.1016/S0006-8993(96)00559-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of bromocriptine and/or L-DOPA on substantia nigra neurons of MPTP-intoxicated mice were investigated. L-DOPA reduced the number of neurons. Bromocriptine protected the neurons from damage by L-DOPA but had no effect on the neurons damaged by MPTP. The treatment of bromocriptine and L-DOPA protected the neurons compared with single administration of bromocriptine. It seems reasonable to suppose that bromocriptine should be added to L-DOPA in order to protect the neurons in parkinsonism.

引用

页码：274 / 276

页数：3

共 12 条

[1] EFFECT OF AGE AT ONSET ON PROGRESSION AND MORTALITY IN PARKINSONS-DISEASE [J].

DIAMOND, SG ;

MARKHAM, CH ;

HOEHN, MM ;

MCDOWELL, FH ;

MUENTER, MD .

NEUROLOGY, 1989, 39 (09) :1187-1190

[2]

FUKUDA T, 1992, CLIN NEUROL, V32, P161

[3] NEUROPATHOLOGY OF IMMUNOHISTOCHEMICALLY IDENTIFIED BRAIN-STEM NEURONS IN PARKINSONS-DISEASE [J].

HALLIDAY, GM ;

LI, YW ;

BLUMBERGS, PC ;

JOH, TH ;

COTTON, RGH ;

HOWE, PRC ;

BLESSING, WW ;

GEFFEN, LB .

ANNALS OF NEUROLOGY, 1990, 27 (04) :373-385

[4] DIFFERENTIAL-EFFECTS OF CHRONIC L-DOPA TREATMENT ON LIPID-PEROXIDATION IN THE MOUSE-BRAIN WITH OR WITHOUT PRETREATMENT WITH 6-HYDROXYDOPAMINE [J].

OGAWA, N ;

ASANUMA, M ;

KONDO, Y ;

KAWADA, Y ;

YAMAMOTO, M ;

MORI, A .

NEUROSCIENCE LETTERS, 1994, 171 (1-2) :55-58

[5]

OGAWA N, 1993, ADV NEUROL, V60, P242

[6] BROMOCRIPTINE PROTECTS MICE AGAINST 6-HYDROXYDOPAMINE AND SCAVENGES HYDROXYL FREE-RADICALS IN-VITRO [J].

OGAWA, N ;

TANAKA, K ;

ASANUMA, M ;

KAWAI, M ;

MASUMIZU, T ;

KOHNO, M ;

MORI, A .

BRAIN RESEARCH, 1994, 657 (1-2) :207-213

[7] DOPAMINE TURNOVER AND GLUTATHIONE OXIDATION - IMPLICATIONS FOR PARKINSON DISEASE [J].

SPINA, MB ;

COHEN, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (04) :1398-1400

[8]

SPINA MB, 1988, J PHARMACOL EXP THER, V247, P502

[9] INHIBITORY EFFECTS OF BROMOCRIPTINE ON PHOSPHOLIPID PEROXIDATION INDUCED BY DOPA AND IRON [J].

TANAKA, M ;

SOTOMATSU, A ;

YOSHIDA, T ;

HIRAI, S .

NEUROSCIENCE LETTERS, 1995, 183 (1-2) :116-119

[10] DEPLETION OF GLUTATHIONE IN BRAIN-STEM OF MICE CAUSED BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE IS PREVENTED BY ANTIOXIDANT PRETREATMENT [J].

YONG, VW ;

PERRY, TL ;

KRISMAN, AA .

NEUROSCIENCE LETTERS, 1986, 63 (01) :56-60

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