The use of mucoadhesive polymers in ocular drug delivery

被引：637

作者：

Ludwig, A ^{[1
]}

机构：

[1] Univ Antwerp, Pharmaceut Technol Lab, B-2610 Antwerp, Belgium

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 11期

关键词：

mucoadhesion; mucins; viscous solution; particulate systems; hydrogel; in situ gelling system; minitablet; insert;

D O I：

10.1016/j.addr.2005.07.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present update on mucoadhesive ocular dosage forms, the tremendous advances in the biochemistry of mucins, the development of new polymers, the use of drug complexes and other technological advances are discussed. This review focusses on recent literature regarding mucoadhesive liquid (viscous solutions, particulate systems), semi-solid (hydrogel, in situ gelling system) and solid dosage forms, with special attention to in vivo studies. Gel-forming minitablets and inserts made of thiomers show an interesting potential for future applications in the treatment of ocular diseases. (c) 2005 Elsevier B.V All rights reserved.

引用

页码：1595 / 1639

页数：45

共 338 条

[41] Pharmacological evaluation of a new timolol/pilocarpine formulation [J].

Bucolo, C ;

Spadaro, A ;

Mangiafico, S .

OPHTHALMIC RESEARCH, 1998, 30 (02) :101-106

[42] Enhanced ocular anti-inflammatory activity of lbuprofen carried by an Eudragit RS100® nanoparticle suspension [J].

Bucolo, C ;

Maltese, A ;

Puglisi, G ;

Pignatello, R .

OPHTHALMIC RESEARCH, 2002, 34 (05) :319-323

[43] Pharmacological profile of a new topical pilocarpine formulation [J].

Bucolo, C ;

Mangiafico, P .

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 1999, 15 (06) :567-573

[44] Surface modifications and molecular imprinting of polymers in medical and pharmaceutical applications [J].

Bures, P ;

Huang, YB ;

Oral, E ;

Peppas, NA .

JOURNAL OF CONTROLLED RELEASE, 2001, 72 (1-3) :25-33

[45] Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes [J].

Burgalassi, S ;

Panichi, L ;

Chetoni, P ;

Saettone, MF ;

Boldrini, E .

OPHTHALMIC RESEARCH, 1999, 31 (03) :229-235

[46] Effect of xyloglucan (tamarind seed polysaccharide) on conjunctival cell adhesion to laminin and on corneal epithelium wound healing [J].

Burgalassi, S ;

Raimondi, L ;

Pirisino, R ;

Banchelli, G ;

Boldrini, E ;

Saettone, MF .

EUROPEAN JOURNAL OF OPHTHALMOLOGY, 2000, 10 (01) :71-76

[47]

Burgalassi S, 1996, EUR J PHARM BIOPHARM, V42, P385

[48] Xyloglucan as a novel vehicle for timolol: Pharmacokinetics and pressure lowering activity in rabbits [J].

Burgalassi, S ;

Chetoni, P ;

Panichi, L ;

Boldrini, E ;

Saettone, MF .

JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2000, 16 (06) :497-509

[49] The treatment of dry eye [J].

Calonge, M .

SURVEY OF OPHTHALMOLOGY, 2001, 45 :S227-S239

[50] Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers [J].

Calvo, P ;

VilaJato, JL ;

Alonso, MJ .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1997, 153 (01) :41-50

← 1 2 3 4 5 6 7 8 9 10 →