The use of mucoadhesive polymers in ocular drug delivery

被引：637

作者：

Ludwig, A ^{[1
]}

机构：

[1] Univ Antwerp, Pharmaceut Technol Lab, B-2610 Antwerp, Belgium

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2005年 / 57卷 / 11期

关键词：

mucoadhesion; mucins; viscous solution; particulate systems; hydrogel; in situ gelling system; minitablet; insert;

D O I：

10.1016/j.addr.2005.07.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present update on mucoadhesive ocular dosage forms, the tremendous advances in the biochemistry of mucins, the development of new polymers, the use of drug complexes and other technological advances are discussed. This review focusses on recent literature regarding mucoadhesive liquid (viscous solutions, particulate systems), semi-solid (hydrogel, in situ gelling system) and solid dosage forms, with special attention to in vivo studies. Gel-forming minitablets and inserts made of thiomers show an interesting potential for future applications in the treatment of ocular diseases. (c) 2005 Elsevier B.V All rights reserved.

引用

页码：1595 / 1639

页数：45

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