Role of dopamine in the motivational and cognitive control of behavior

被引：259

作者：

Cools, Roshan ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands

来源：

NEUROSCIENTIST | 2008年 / 14卷 / 04期

关键词：

dopamine; motivation; reward; punishment; impulsivity; cognitive flexibility; working memory;

D O I：

10.1177/1073858408317009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain dopamine has often been implicated in impulsive and/or inflexible behaviors, which may reflect failures of motivational and/or cognitive control. However, the precise role of dopamine in such failures of behavioral control is not well understood, not least because they implicate paradoxical changes in distinct dopamine systems that innervate dissociable neural circuits. In addition, there are large individual differences in the response to dopaminergic drugs with some individuals benefiting from and others being impaired by the same drug. This complicates progress in the understanding of dopamine's role in behavioral control processes, but also provides a major problem for neuropsychiatry, where some individuals are disproportionately vulnerable to the adverse effects of dopamine-enhancing drugs on motivation and cognition. Recent progress is reviewed from cognitive and behavioral neuroscience research on motivation and cognitive control, which begins to elucidate the factors that mediate the complex roles of mesolimbic, mesocortical, and nigrostriatal dopamine in behavioral control.

引用

页码：381 / 395

页数：15

共 94 条

[1]

Akil M, 2003, J NEUROSCI, V23, P2008

[2] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].

ALEXANDER, GE ;

DELONG, MR ;

STRICK, PL .

ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381

[3]

[Anonymous], 1967, INTEGRATIVE ACTIVITY

[4] Tolcapone improves cognition and cortical information processing in normal human subjects [J].

Apud, Jose A. ;

Mattay, Venkata ;

Chen, Jingshan ;

Kolachana, Bhaskar S. ;

Callicott, Joseph H. ;

Rasetti, Roberta ;

Alce, Guilna ;

Iudicello, Jennifer E. ;

Akbar, Natkai ;

Egan, Michael F. ;

Goldberg, Terry E. ;

Weinberger, Daniel R. .

NEUROPSYCHOPHARMACOLOGY, 2007, 32 (05) :1011-1020

[5] Catecholamine modulation of prefrontal cortical cognitive function [J].

Arnsten, AFT .

TRENDS IN COGNITIVE SCIENCES, 1998, 2 (11) :436-447

[6] The neural basis of inhibition in cognitive control [J].

Aron, Adam R. .

NEUROSCIENTIST, 2007, 13 (03) :214-228

[7] Discrete neurochemical coding of distinguishable motivational processes: insights from nucleus accumbens control of feeding [J].

Baldo, Brian A. ;

Kelley, Ann E. .

PSYCHOPHARMACOLOGY, 2007, 191 (03) :439-459

[8] What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? [J].

Berridge, KC ;

Robinson, TE .

BRAIN RESEARCH REVIEWS, 1998, 28 (03) :309-369

[9] Additive effects of genetic variation in dopamine regulating genes on working memory cortical activity in human brain [J].

Bertolino, A ;

Blasi, G ;

Latorre, V ;

Rubino, V ;

Rampino, A ;

Sinibaldi, L ;

Caforio, G ;

Petruzzella, V ;

Pizzuti, A ;

Scarabino, T ;

Nardini, M ;

Weinberger, DR ;

Dallapiccola, B .

JOURNAL OF NEUROSCIENCE, 2006, 26 (15) :3918-3922

[10] The catechol-O-methyltransferase polymorphism:: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes [J].

Bilder, RM ;

Volavka, J ;

Lachman, HM ;

Grace, AA .

NEUROPSYCHOPHARMACOLOGY, 2004, 29 (11) :1943-1961

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