Role of dopamine in the motivational and cognitive control of behavior

被引：259

作者：

Cools, Roshan ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands

来源：

NEUROSCIENTIST | 2008年 / 14卷 / 04期

关键词：

dopamine; motivation; reward; punishment; impulsivity; cognitive flexibility; working memory;

D O I：

10.1177/1073858408317009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain dopamine has often been implicated in impulsive and/or inflexible behaviors, which may reflect failures of motivational and/or cognitive control. However, the precise role of dopamine in such failures of behavioral control is not well understood, not least because they implicate paradoxical changes in distinct dopamine systems that innervate dissociable neural circuits. In addition, there are large individual differences in the response to dopaminergic drugs with some individuals benefiting from and others being impaired by the same drug. This complicates progress in the understanding of dopamine's role in behavioral control processes, but also provides a major problem for neuropsychiatry, where some individuals are disproportionately vulnerable to the adverse effects of dopamine-enhancing drugs on motivation and cognition. Recent progress is reviewed from cognitive and behavioral neuroscience research on motivation and cognitive control, which begins to elucidate the factors that mediate the complex roles of mesolimbic, mesocortical, and nigrostriatal dopamine in behavioral control.

引用

页码：381 / 395

页数：15

共 94 条

[11] COGNITIVE DEFICIT CAUSED BY REGIONAL DEPLETION OF DOPAMINE IN PREFRONTAL CORTEX OF RHESUS-MONKEY [J].

BROZOSKI, TJ ;

BROWN, RM ;

ROSVOLD, HE ;

GOLDMAN, PS .

SCIENCE, 1979, 205 (4409) :929-932

[12] Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects [J].

Caldu, Xavier ;

Vendrell, Pere ;

Bartres-Faz, David ;

Clemente, Inmaculada ;

Bargallo, Nuria ;

Jurado, Maria Angeles ;

Serra-Grabulosa, Josep Maria ;

Junque, Carme .

NEUROIMAGE, 2007, 37 (04) :1437-1444

[13] Limbic corticostriatal systems and delayed reinforcement [J].

Cardinal, RN ;

Winstanley, CA ;

Robbins, TW ;

Everitt, BJ .

ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES, 2004, 1021 :33-50

[14] Functional analysis of genetic variation in catechol-o-methyltransferase (COMT):: Effects on mRNA, protein, and enzyme activity in postmortem human brain [J].

Chen, JS ;

Lipska, BK ;

Halim, N ;

Ma, QD ;

Matsumoto, M ;

Melhem, S ;

Kolachana, BS ;

Hyde, TM ;

Herman, MM ;

Apud, J ;

Egan, MF ;

Kleinman, JE ;

Weinberger, DR .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (05) :807-821

[15] Association between response inhibition and working memory in adult ADHD: A link to right frontal cortex pathology? [J].

Clark, Luke ;

Blackwell, Andrew D. ;

Aron, Adam R. ;

Turner, Danielle C. ;

Dowson, Jonathan ;

Robbins, Trevor W. ;

Sahakian, Barbara J. .

BIOLOGICAL PSYCHIATRY, 2007, 61 (12) :1395-1401

[16] Dopamine gene predicts the brain's response to dopaminergic drug [J].

Cohen, Michael X. ;

Krohn-Grimberghe, Artus ;

Elger, Christian E. ;

Weber, Bernd .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 26 (12) :3652-3660

[17] Individual differences in extraversion and dopamine genetics predict neural reward responses [J].

Cohen, MX ;

Young, J ;

Baek, JM ;

Kessler, C ;

Ranganath, C .

COGNITIVE BRAIN RESEARCH, 2005, 25 (03) :851-861

[18]

Congdon Eliza, 2005, Behav Cogn Neurosci Rev, V4, P262, DOI 10.1177/1534582305285980

[19]

COOLS AR, 1980, BEHAV BRAIN RES, V1, P361, DOI 10.1016/S0166-4328(80)80073-8

[20] COGNITIVE AND MOTOR SHIFTING APTITUDE DISORDER IN PARKINSONS-DISEASE [J].

COOLS, AR ;

VANDENBERCKEN, JHL ;

HORSTINK, MWI ;

VANSPAENDONCK, KPM ;

BERGER, HJC .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1984, 47 (05) :443-453

← 1 2 3 4 5 6 7 8 9 10 →