Role of dopamine in the motivational and cognitive control of behavior

被引：259

作者：

Cools, Roshan ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, FC Donders Ctr Cognit Neuroimaging, NL-6500 HB Nijmegen, Netherlands

来源：

NEUROSCIENTIST | 2008年 / 14卷 / 04期

关键词：

dopamine; motivation; reward; punishment; impulsivity; cognitive flexibility; working memory;

D O I：

10.1177/1073858408317009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Brain dopamine has often been implicated in impulsive and/or inflexible behaviors, which may reflect failures of motivational and/or cognitive control. However, the precise role of dopamine in such failures of behavioral control is not well understood, not least because they implicate paradoxical changes in distinct dopamine systems that innervate dissociable neural circuits. In addition, there are large individual differences in the response to dopaminergic drugs with some individuals benefiting from and others being impaired by the same drug. This complicates progress in the understanding of dopamine's role in behavioral control processes, but also provides a major problem for neuropsychiatry, where some individuals are disproportionately vulnerable to the adverse effects of dopamine-enhancing drugs on motivation and cognition. Recent progress is reviewed from cognitive and behavioral neuroscience research on motivation and cognitive control, which begins to elucidate the factors that mediate the complex roles of mesolimbic, mesocortical, and nigrostriatal dopamine in behavioral control.

引用

页码：381 / 395

页数：15

共 94 条

[41] Dopamine modulation in the basal ganglia locks the gate to working memory [J].

Gruber, Aaron J. ;

Dayan, Peter ;

Gutkin, Boris S. ;

Solla, Sara A. .

JOURNAL OF COMPUTATIONAL NEUROSCIENCE, 2006, 20 (02) :153-166

[42] Genotype influences in vivo dopamine transporter availability in human striatum [J].

Heinz, A ;

Goldman, D ;

Jones, DW ;

Palmour, R ;

Hommer, D ;

Gorey, JG ;

Lee, KS ;

Linnoila, M ;

Winberger, DR .

NEUROPSYCHOPHARMACOLOGY, 2000, 22 (02) :133-139

[43] C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo [J].

Hirvonen, M ;

Laakso, A ;

Någren, K ;

Rinne, JO ;

Pohjalainen, T ;

Hietala, J .

MOLECULAR PSYCHIATRY, 2004, 9 (12) :1060-1061

[44] Personality factors moderate subjective and psychophysiological responses to d-amphetamine in humans [J].

Hutchison, KE ;

Wood, MD ;

Swift, R .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 1999, 7 (04) :493-501

[45] The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking [J].

Ikemoto, S ;

Panksepp, J .

BRAIN RESEARCH REVIEWS, 1999, 31 (01) :6-41

[46] Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys [J].

James, Alex S. ;

Groman, Stephanie M. ;

Seu, Emanuele ;

Jorgensen, Matthew ;

Fairbanks, Lynn A. ;

Jentsch, J. David .

JOURNAL OF NEUROSCIENCE, 2007, 27 (52) :14358-14364

[47] Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli [J].

Jentsch, JD ;

Taylor, JR .

PSYCHOPHARMACOLOGY, 1999, 146 (04) :373-390

[48] Effects of bromocriptine on human subjects depend on working memory capacity [J].

Kimberg, DY ;

DEsposito, M ;

Farah, MJ .

NEUROREPORT, 1997, 8 (16) :3581-3585

[49] Imaging gene-substance interactions: The effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward [J].

Kirsch, Peter ;

Reuter, Martin ;

Mier, Daniela ;

Lonsdorf, Tina ;

Stark, Rudolf ;

Gallhofer, Bernd ;

Vaitl, Dieter ;

Hennig, Juergen .

NEUROSCIENCE LETTERS, 2006, 405 (03) :196-201

[50] UNEVEN PATTERN OF DOPAMINE LOSS IN THE STRIATUM OF PATIENTS WITH IDIOPATHIC PARKINSONS-DISEASE - PATHOPHYSIOLOGIC AND CLINICAL IMPLICATIONS [J].

KISH, SJ ;

SHANNAK, K ;

HORNYKIEWICZ, O .

NEW ENGLAND JOURNAL OF MEDICINE, 1988, 318 (14) :876-880

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