Changing Trends in Antimicrobial Resistance and Serotypes of Streptococcus pneumoniae Isolates in Asian Countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study

被引：283

作者：

Kim, So Hyun ^{[1
]}

Song, Jae-Hoon ^{[1
,2
]}

Chung, Doo Ryeon ^{[2
]}

Thamlikitkul, Visanu ^{[3
]}

Yang, Yonghong ^{[4
]}

Wang, Hui ^{[5
]}

Lu, Min ^{[6
]}

So, Thomas Man-Kit ^{[8
]}

Hsueh, Po-Ren ^{[7
]}

Yasin, Rohani M. ^{[10
]}

Carlos, Celia C. ^{[9
]}

Hung Van Pham ^{[11
]}

Lalitha, M. K. ^{[12
]}

Shimono, Nobuyuki ^{[14
]}

Perera, Jennifer ^{[13
]}

Shibl, Atef M. ^{[15
]}

Baek, Jin Yang ^{[1
]}

Kang, Cheol-In ^{[2
]}

Ko, Kwan Soo ^{[1
]}

Peck, Kyong Ran ^{[2
,16
]}

机构：

[1] APFID, Seoul, South Korea

[2] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea

[3] Mahidol Univ, Siriraj Hosp, Bangkok 10700, Thailand

[4] Capital Med Univ, Beijing Childrens Hosp, Beijing, Peoples R China

[5] Beijing Union Med Coll Hosp, Beijing, Peoples R China

[6] Jiao Tong Univ, Shanghai Childrens Hosp, Shanghai 200030, Peoples R China

[7] Natl Taiwan Univ, Coll Med, Natl Taiwan Univ Hosp, Taipei 10764, Taiwan

[8] Princess Margaret Hosp, Kwai Chung, Hong Kong, Peoples R China

[9] Res Inst Trop Med, Antimicrobial Resistance Surveillance Reference L, Manila, Philippines

[10] Inst Med Res, Kuala Lumpur 50588, Malaysia

[11] Univ Med & Pharm, Fac Med, Ho Chi Minh City, Vietnam

[12] Madras Med Mission, Madras, Tamil Nadu, India

[13] Univ Colombo, Colombo, Sri Lanka

[14] Kyushu Univ Hosp, Fukuoka 812, Japan

[15] King Saud Univ Hosp, Riyadh, Saudi Arabia

[16] Sungkyunkwan Univ, Sch Med, Dept Mol Cell Biol, Suwon, South Korea

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2012年 / 56卷 / 03期

关键词：

PNEUMOCOCCAL CONJUGATE VACCINE; MACROLIDE RESISTANCE; UNITED-STATES; CHILDREN; DISEASE; 19A; CARRIAGE; KOREA;

D O I：

10.1128/AAC.05658-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin-nonsusceptible pneumococci (MIC, >= 4 mu g/ml) was 4.6% and penicillin resistance (MIC, >= 8 mu g/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A.

引用

页码：1418 / 1426

页数：9

共 26 条

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