Methods of investigation for cardiac autonomic dysfunction in human research studies

被引:120
作者
Bernardi, Luciano [1 ,2 ]
Spallone, Vincenza [3 ]
Stevens, Martin [4 ]
Hilsted, Jannik [5 ]
Frontoni, Simona [3 ]
Pop-Busui, Rodica [6 ]
Ziegler, Dan [7 ]
Kempler, Peter [8 ]
Freeman, Roy [9 ]
Low, Phillip [10 ]
Tesfaye, Solomon [11 ]
Valensi, Paul [12 ]
机构
[1] IRCCS S Matteo, Dept Internal Med, Pavia, Italy
[2] Univ Pavia, I-27100 Pavia, Italy
[3] Univ Roma Tor Vergata, Dept Internal Med, Rome, Italy
[4] Univ Birmingham, Dept Med, Birmingham, W Midlands, England
[5] Copenhagen Univ Hosp, Copenhagen, Denmark
[6] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA
[7] Univ Dusseldorf, German Diabet Ctr, Leibniz Ctr Diabet Res, Inst Clin Diabetol, D-40225 Dusseldorf, Germany
[8] Semmelweis Univ, Dept Med, Budapest, Hungary
[9] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Boston, MA 02215 USA
[10] Mayo Clin, Dept Neurol, Rochester, MN USA
[11] Sheffield Teaching Hosp, Diabet Res Unit, Sheffield, S Yorkshire, England
[12] Univ Paris 13, Hop Jean Verdier, AP HP, Serv Endocrinol Diabetol Nutr,CRNH IdF, Bondy, France
关键词
diabetic neuropathy; heart rate variability; baroreflex sensitivity; microneurography; catecholamines; cardiac imaging; HEART-RATE-VARIABILITY; SYMPATHETIC-NERVE ACTIVITY; BAROREFLEX SENSITIVITY; DIABETIC-PATIENTS; SYMPATHOVAGAL BALANCE; SPECTRAL-ANALYSIS; C-11; HYDROXYEPHEDRINE; BLOOD-PRESSURE; WEIGHT-LOSS; NEUROPATHY;
D O I
10.1002/dmrr.1224
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This consensus document provides evidence-based guidelines regarding the evaluation of diabetic cardiovascular autonomic neuropathy (CAN) for human research studies; the guidelines are the result of the work of the CAN Subcommittee of the Toronto Diabetic Neuropathy Expert Group. The subcommittee critically reviewed the limitations and strengths of the available diagnostic approaches for CAN and the need for developing new tests for autonomic function. It was concluded that the most sensitive and specific approaches currently available to evaluate CAN in clinical research are: (1) heart rate variability, (2) baroreflex sensitivity, (3) muscle sympathetic nerve activity, (4) plasma catecholamines, and (5) heart sympathetic imaging. It was also recommended that efforts should be undertaken to develop new non-invasive and safe CAN tests to be used in clinical research, with higher sensitivity and specificity, for studying the pathophysiology of CAN and evaluating new therapeutic approaches. Copyright (C) 2011 John Wiley & Sons, Ltd.
引用
收藏
页码:654 / 664
页数:11
相关论文
共 60 条
[31]   CATECHOLAMINES AND DIABETIC AUTONOMIC NEUROPATHY [J].
HILSTED, J .
DIABETIC MEDICINE, 1995, 12 (04) :296-297
[32]   Microneurographically determined muscle sympathetic nerve activity levels are reproducible in insulin-dependent diabetes mellitus [J].
Hoffman, RP ;
Sinkey, CA ;
Anderson, EA .
JOURNAL OF DIABETES AND ITS COMPLICATIONS, 1998, 12 (06) :307-310
[33]   Disparity of autonomic control in type 2 diabetes mellitus [J].
Huggett, RJ ;
Scott, EM ;
Gilbey, SG ;
Bannister, J ;
Mackintosh, AF ;
Mary, DASG .
DIABETOLOGIA, 2005, 48 (01) :172-179
[34]   Baroreflex effectiveness index and baroreflex sensitivity predict all-cause mortality and sudden death in hypertensive patients with chronic renal failure [J].
Johansson, Mats ;
Gao, Sinsia A. ;
Friberg, Peter ;
Annerstedt, Marita ;
Carlstrom, Jan ;
Ivarsson, Ted ;
Jensen, Gert ;
Ljungman, Susanne ;
Mathillas, Oivind ;
Nielsen, Finn-David ;
Strombom, Ulf .
JOURNAL OF HYPERTENSION, 2007, 25 (01) :163-168
[35]   Prognostic Implications of Baroreflex Sensitivity in Heart Failure Patients in the Beta-Blocking Era [J].
La Rovere, Maria Teresa ;
Pinna, Gian Domenico ;
Maestri, Roberto ;
Robbi, Elena ;
Caporotondi, Angelo ;
Guazzotti, Gianpaolo ;
Sleight, Peter ;
Febo, Oreste .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 53 (02) :193-199
[36]  
La Rovere MT, 1998, LANCET, V351, P478
[37]   Exercise training improves baroreflex sensitivity in type 2 diabetes [J].
Loimaala, A ;
Huikuri, HV ;
Kööbi, T ;
Rinne, M ;
Nenonen, A ;
Vuori, I .
DIABETES, 2003, 52 (07) :1837-1842
[38]  
Malliani A, 1998, CIRCULATION, V98, P2640
[39]   Measurement of myocardial accumulation of I-123-metaiodabenzylguanidine for studying cardiac autonomic neuropathy in diabetes mellitus [J].
Mantysaari, M ;
Kuikka, J ;
Mustonen, J ;
Tahvanainen, K ;
Vanninen, E ;
Lansimies, E ;
Uusitupa, M .
CLINICAL AUTONOMIC RESEARCH, 1996, 6 (03) :163-169
[40]   An Overview of the Effect of Weight Loss on Cardiovascular Autonomic Function [J].
Maser, Raelene E. ;
Lenhard, M. James .
CURRENT DIABETES REVIEWS, 2007, 3 (03) :204-211