Rh-Catalyzed Intermolecular Carbenoid Functionalization of Aromatic C-H Bonds by α-Diazomalonates

被引：424

作者：

Chan, Wai-Wing

Lo, Siu-Fung

Zhou, Zhongyuan

Yu, Wing-Yiu ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 33期

关键词：

CROSS-COUPLING REACTION; TERT-BUTYL HYDROPEROXIDE; STEREOSELECTIVE-SYNTHESIS; N-CHLOROAMINES; PALLADIUM; ACTIVATION; INSERTION; ARYL; DIAZOESTERS; ALDEHYDES;

D O I：

10.1021/ja305771y

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A Rh-catalyzed intermolecular coupling of diazomalonates with arene C H bonds is reported. The reaction is initiated by electrophilic C H activation, which is followed by coupling of the arylrhodium(III) complex with the diazomalonate. In most cases, arenes with oximes, carboxylic acids, and amines as directing groups cross couple with diazomalonates with excellent regioselectivities and functional group tolerance, and thus, this reaction offers a new route to alpha-aryl carbonyl compounds for specific applications.

引用

页码：13565 / 13568

页数：4

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