Pd-Catalyzed Ortho-C HAcylation/Cross Coupling of Aryl Ketone O-Methyl Oximes with Aldehydes Using tert-Butyl Hydroperoxide as Oxidant

被引：214

作者：

Chan, Chun-Wo

Zhou, Zhongyuan

Chan, Albert S. C.

Yu, Wing-Yiu ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, State Key Lab Chirosci, Kowloon, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 17期

关键词：

H BOND FUNCTIONALIZATION; ORTHO-ARYLATION; ORGANIC-SYNTHESIS; ACYL RADICALS; DIRECT ACCESS; SP(2); COMPLEXES; BROMIDES; IODIDES; ACIDS;

D O I：

10.1021/ol101618u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Pd-catalyzed protocol for direct C-H bond acylation by cross coupling of aryl ketone oximes and aldehydes using fert-butyl hydroperoxide (TBHP) as oxidant was developed. With oximes as a directing group for the C-H activation, the coupling with aldehydes was achieved with remarkable regioselectivity. The acylation reactions exhibit excellent functional group tolerance, and both aliphatic and heteroaromatic aldehydes can be effectively coupled to the oximes.

引用

页码：3926 / 3929

页数：4

共 60 条

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