Copper-catalyzed amination of aromatic halides with 2-N,N-dimethylaminoethanol as solvent

被引：101

作者：

Lu, ZK ^{[1
]}

Twieg, RJ ^{[1
]}

Huang, SPD ^{[1
]}

机构：

[1] Kent State Univ, Dept Chem, Kent, OH 44242 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 33期

关键词：

D O I：

10.1016/S0040-4039(03)01536-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed amination of aromatic halides under mild conditions using N,N-dimethylaminoethanol as solvent is described. We have studied this reaction in some detail varying the copper source. base, water content and other parameters including the scope of useful amine and aromatic halide structures. A variety of 4-halo-N,N-cycloalkylanilines and 2-N,N-cycloalkylaminothiophenes were synthesized for further elaboration into chromophores for optoclectronic applications. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：6289 / 6292

页数：4

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