Myometrial cytokines and their role in the onset of labour

被引：59

作者：

Sivarajasingam, S. P. ^{[1
]}

Imami, N. ^{[2
]}

Johnson, M. R. ^{[1
]}

机构：

[1] Imperial Coll London, Chelsea & Westminster Hosp, Dept Surg & Canc, London, England

[2] Imperial Coll London, Dept Med, London, England

来源：

JOURNAL OF ENDOCRINOLOGY | 2016年 / 231卷 / 03期

关键词：

inflammatory diseases; labour; cytokines; reproduction; SMOOTH-MUSCLE-CELLS; CORTICOTROPIN-RELEASING HORMONE; FACTOR-KAPPA-B; LOWER UTERINE SEGMENT; AMNIOTIC-FLUID INTERLEUKIN-6; MESSENGER-RIBONUCLEIC-ACID; PRETERM PREMATURE RUPTURE; HUMAN PREGNANT MYOMETRIUM; HUMAN GESTATIONAL TISSUES; ACTIVATED PROTEIN-KINASE;

D O I：

10.1530/JOE-16-0157

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Human labour is an inflammatory event, physiologically driven by an interaction between hormonal and mechanical factors and pathologically associated with infection, bleeding and excessive uterine stretch. The initiation and communicators of inflammation is still not completely understood; however, a key role for cytokines has been implicated. We summarise the current understanding of the nature and role of cytokines, chemokines and hormones and their involvement in signalling within the myometrium particularly during labour.

引用

页码：R101 / R119

页数：19

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