Diastereoselective synthesis of N-protected β-amino-α-hydroxyacids (norstatines) from urethane N-carboxyanhydrides (UNCAs)

被引：4

作者：

Audin, P

Pothion, C

Fehrentz, JA

Loffet, A

Martinez, J

Paris, J

机构：

[1] ISPB, Chim Therapeut Lab, F-69373 Lyon 08, France

[2] Univ Montpellier 1, CNRS, UMR 5810, LAPP,Fac Pharm, F-34060 Montpellier, France

[3] Univ Montpellier 2, CNRS, UMR 5810, LAPP,Fac Pharm, F-34060 Montpellier, France

[4] Senn Chem Int, F-94250 Gentilly, France

来源：

JOURNAL OF CHEMICAL RESEARCH | 1999年 / 04期

关键词：

D O I：

10.1039/a809421g

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

beta-Amino-alpha-hydroxyacids (norstatines) are prepared from urethane N-protected carboxyanhydrides (UNCAs); the key step is the diastereoselective reduction of a keto-acetylenic compound, which lead is, with syn diastereoselectivity, to the corresponding propargylic alcohol.

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页码：282 / 283

页数：2

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