SYNTHESIS OF CHIRAL N-PROTECTED BETA-AMINO ALCOHOLS BY THE USE OF UNCAS

被引：24

作者：

FEHRENTZ, JA

CALIFANO, JC

AMBLARD, M

MARTINEZ, J

LOFFET, A

机构：

[1] FAC PHARM MONTPELLIER,CNRS,CHIM & PHARMACOL MOLECULES INTERET BIOL LAB,F-34060 MONTPELLIER,FRANCE

[2] PROPEPTIDE,F-91710 VERT LE PETIT,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 04期

关键词：

D O I：

10.1016/S0040-4039(00)75840-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of a wide variety of N-protected beta-amino alcohol derivatives under mild conditions is described. N-urethane protected amino acid N-carboxyanhydrides (UNCAs) were used as starting material and reduced into the corresponding alcohols with the appropriate hydride, sodium borohydride. The reaction is simple, unexpensive, easily scaled up, and proceeds without observable racemization.

引用

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页码：569 / 571

页数：3

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