The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents

被引:7
作者
Drew, MGB [1 ]
Gorsuch, S [1 ]
Gould, JHM [1 ]
Mann, J [1 ]
机构
[1] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1999年 / 08期
关键词
D O I
10.1039/a900800d
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
(5S)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H)-one has been converted into cytosine 2',3'-dideoxy-3',5'-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.
引用
收藏
页码:969 / 978
页数:10
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