Preparation and characterization of macroporous chitosan-gelatin β-tricalcium phosphate composite scaffolds for bone tissue engineering

被引：174

作者：

Yin, YJ

Ye, F

Cui, JF

Zhang, FJ

Li, XL

Yao, KD ^{[1
]}

机构：

[1] Tianjin Univ, Res Inst Polymer Mat, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Res Inst Polymer Mat, Tianjin 300072, Peoples R China

[3] Tianjin Hosp, Tianjin 300072, Peoples R China

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2003年 / 67A卷 / 03期

关键词：

chitosan-gelatin hybrid polymer network; beta-tricalcium phosphate; composite scaffold; microstructure; mechanical properties; biocompatibility;

D O I：

10.1002/jbm.a.10153

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A biodegradable composite scaffold was developed using beta-tricalcium phosphate (beta-TCP) with chitosan (CS) and gelatin (Gel) in the form of a hybrid polymer network (HPN) via co-crosslinking with glutaraldehyde. Various types of scaffolds were prepared by freezing and lyophilizing. These scaffolds were characterized by Fourier transform infrared, X-ray diffractometer, and scanning electron microscopy. The macroporous composite scaffolds exhibited different pore structures. Compressive properties were improved, especially compressive modulus from 3.9-10.9 MPa. Biocompatibility was evaluated subcutaneously on rabbits. A mild inflammatory response was observed over 12 weeks. The results suggest that the scaffolds can be utilized in nonloading bone regeneration. (C) 2003 Wiley Periodicals, Inc.

引用

页码：844 / 855

页数：12

共 52 条

[11] Mechanical properties and transition temperatures of crosslinked oriented gelatin .1. Static and dynamic mechanical properties of cross-linked gelatin [J].