A minimal avian retroviral packaging sequence has a complex structure

被引：40

作者：

Banks, JD

Yeo, A

Green, K

Cepeda, F

Linial, ML ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

[2] Univ Washington, Dept Microbiol, Seattle, WA 98195 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 07期

关键词：

D O I：

10.1128/JVI.72.7.6190-6194.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have defined a 160-nucleotide region, M psi, from the 5' leader region of the Rous sarcoma virus genome that is sufficient to direct the packaging of a heterologous RNA. M psi contains the putative O3 stem structure that has previously been shown, and that has been confirmed in this study, to be important for the efficient packaging of avian leukosis-sarcoma virus RNA. Analyses of several O3 stem mutants revealed that other regions within M psi can interfere with the proper folding of altered sequences which are predicted to form a wild-type O3 stem.

引用

页码：6190 / 6194

页数：5

共 15 条

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