Early mouse development: Lessons from gene targeting

被引：29

作者：

StJacques, B

McMahon, AP

机构：

[1] Dept. of Molec. and Cellular Biology, Harvard University, Biological Laboratories, Cambridge, MA 02138

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/S0959-437X(96)80065-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A number of mouse mutants generated recently by gene targeting are of particular interest for the study of development. For some genes, such as Lim1 or Otx-2, recent knockouts reveal an essential role in early patterning. In other cases, such as the activins and goosecoid, the mutant phenotypes force a re-evaluation of models that are based on studies in other vertebrates. Of particular interest also are the new compound mutants for genes where some measure of functional redundancy is expected, notably the Hox genes. Finally, recent technical advances allow the creation of conditional knockouts as well as large chromosomal alterations.

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收藏

页码：439 / 444

页数：6

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