Dementia with Lewy bodies and Alzheimer's disease

被引:27
作者
Rosenberg, CK
Cummings, TJ
Saunders, AM
Widico, C
McIntyre, LM
Hulette, CM
机构
[1] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Med, Div Neurol,Bryan Alzheimers Dis Res Ctr, Durham, NC 27710 USA
关键词
Alzheimer's disease; apolipoprotein E; dementia with Lewy bodies;
D O I
10.1007/s004010100415
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To investigate similarities and differences between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), we undertook a demographic analysis of 277 patients from the Kathleen Price Bryan Brain Bank with an antemortem diagnosis of probable AD. Patients with additional, possibly confounding clinical and pathologic diagnoses such as infarcts, hematomas, neoplasms, and other neurodegenerative disorders, were excluded from the analysis. Neuropathologically, AD alone was present in 192 subjects (69%), and DLB was found in 85 subjects (31%). All of the DLB cases had neuropathologic evidence of AD sufficient to meet CERAD criteria for a diagnosis of definite AD plus nigral Lewy bodies. Gender, apolipoprotein E (APOE) genotype, brain weight, age at death, duration of disease and Braak stage were compared between the two groups. Statistical analyses were performed using Fisher's exact test for comparisons of categorical data and Student's t-test for comparison of means for continuous outcomes. The proportion of males and females was balanced in the combined AD and DLB populations. There was a highly statistically significant increased frequency of APOE 3/4 in males with DLB (P=0.007). We found higher brain weights in males with DLB versus males with AD (P=0.012). AD was more frequent in females and DLB was more frequent in males (P=0.019). Our findings with respect to age at death, duration of disease and Braak stage within diagnostic groups confirm previously reported findings. These data suggest that Lewy bodies are more common in males affected with dementia, especially those with the APOE 3/4 genotype.
引用
收藏
页码:621 / 626
页数:6
相关论文
共 49 条
[1]   LEWY BODIES CONTAIN BETA-AMYLOID PRECURSOR PROTEINS OF ALZHEIMERS-DISEASE [J].
ARAI, H ;
LEE, VMY ;
HILL, WD ;
GREENBERG, BD ;
TROJANOWSKI, JQ .
BRAIN RESEARCH, 1992, 585 (1-2) :386-390
[2]   NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].
ARRIAGADA, PV ;
GROWDON, JH ;
HEDLEYWHYTE, ET ;
HYMAN, BT .
NEUROLOGY, 1992, 42 (03) :631-639
[3]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER LESIONS AND INTELLECTUAL STATUS IN ALZHEIMERS AND PARKINSONS-DISEASE PATIENTS [J].
BANCHER, C ;
BRAAK, H ;
FISCHER, P ;
JELLINGER, KA .
NEUROSCIENCE LETTERS, 1993, 162 (1-2) :179-182
[4]   NEUROPATHOLOGICAL INDEXES OF ALZHEIMERS-DISEASE IN DEMENTED AND NONDEMENTED PERSONS AGED 80 YEARS AND OLDER [J].
BERG, L ;
MCKEEL, DW ;
MILLER, JP ;
BATY, J ;
MORRIS, JC .
ARCHIVES OF NEUROLOGY, 1993, 50 (04) :349-358
[5]  
BERGERON C, 1989, Alzheimer Disease and Associated Disorders, V3, P197, DOI 10.1097/00002093-198903040-00002
[6]   NEOCORTICAL NEUROFIBRILLARY TANGLES CORRELATE WITH DEMENTIA SEVERITY IN ALZHEIMERS-DISEASE [J].
BIERER, LM ;
HOF, PR ;
PUROHIT, DP ;
CARLIN, L ;
SCHMEIDLER, J ;
DAVIS, KL ;
PERL, DP .
ARCHIVES OF NEUROLOGY, 1995, 52 (01) :81-88
[7]   NEUROPATHOLOGICAL STAGING OF ALZHEIMER-RELATED CHANGES [J].
BRAAK, H ;
BRAAK, E .
ACTA NEUROPATHOLOGICA, 1991, 82 (04) :239-259
[8]   Neocortical synapse density and braak stage in the lewy body variant of Alzheimer disease: A comparison with classic Alzheimer disease and normal aging [J].
Brown, DF ;
Risser, RC ;
Bigio, EH ;
Tripp, P ;
Stiegler, A ;
Welch, E ;
Eagan, KP ;
Hladik, CL ;
White, CL .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (10) :955-960
[9]   Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies [J].
Chinnery, PF ;
Taylor, GA ;
Howell, N ;
Andrews, RM ;
Morris, CM ;
Taylor, RW ;
McKeith, IG ;
Perry, RH ;
Edwardson, JA ;
Turnbull, DM .
NEUROLOGY, 2000, 55 (02) :302-304
[10]   GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].
CORDER, EH ;
SAUNDERS, AM ;
STRITTMATTER, WJ ;
SCHMECHEL, DE ;
GASKELL, PC ;
SMALL, GW ;
ROSES, AD ;
HAINES, JL ;
PERICAKVANCE, MA .
SCIENCE, 1993, 261 (5123) :921-923