Opinion - Genomic fluidity and pathogenic bacteria: applications in diagnostics, epidemiology and intervention

被引：136

作者：

Ahmed, Niyaz ^{[2
]}

Dobrindt, Ulrich ^{[1
]}

Hacker, Joerg ^{[1
,3
]}

Hasnain, Seyed E. ^{[4
,5
,6
]}

机构：

[1] Univ Wurzburg, Inst Mol Biol Infect Dis, D-97070 Wurzburg, Germany

[2] Ctr DNA Fingerpriting & Diagnost, Pathogen Evolut Lab, Hyderabad 500076, Andhra Pradesh, India

[3] Robert Koch Inst, D-13353 Berlin, Germany

[4] Univ Hyderabad, Hyderabad 500046, Andhra Pradesh, India

[5] Inst Life Sci, Hyderabad 500046, Andhra Pradesh, India

[6] Indian Inst Sci, Jawaharlal Nehru Ctr Adv Sci Res, Bangalore 560064, Karnataka, India

来源：

NATURE REVIEWS MICROBIOLOGY | 2008年 / 6卷 / 05期

关键词：

D O I：

10.1038/nrmicro1889

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The increasing availability of DNA-sequence information for multiple pathogenic and non-pathogenic variants of individual bacterial species has indicated that both DNA acquisition and genome reduction have important roles in genome evolution. Such genomic fluidity, which is found in human pathogens such as Escherichia coli, Helicobacter pylori and Mycobacterium tuberculosis, has important consequences for the clinical management of the diseases that are caused by these pathogens and for the development of diagnostics and new molecular epidemiological methods.

引用

页码：387 / 394

页数：8

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