"Point" Centromeres of Saccharomyces Harbor Single Centromere-Specific Nucleosomes

被引：37

作者：

Henikoff, Steven ^{[1
,2
]}

Henikoff, Jorja G. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98109 USA

[2] Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA

来源：

GENETICS | 2012年 / 190卷 / 04期

关键词：

CSE4; COMPONENT; DNA;

D O I：

10.1534/genetics.111.137711

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The "point" centromere of budding yeast is genetically defined by an similar to 125-bp sequence. Recent fluorescence measurements of kinetochore clusters have suggested that this sequence specifies multiple centromere histone 3 (CenH3) nucleosomes. However, high-resolution mapping demonstrates that there is only one CenH3 nucleosome per centromere, providing biochemical confirmation of the point centromere model.

引用

页码：1575 / 1577

页数：3

共 14 条

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